Observational cohort study designed to identify the mechanisms of disease in patients with preterm labor/contractions and preterm premature rupture of membranes and to describe the relationship between clinical, biochemical, histological, biophysical parameters and the development of infant neurological disorders.
Study is to determine if a weekly dose of 17P (Progesterone) given to women with preterm rupture of the membranes will: increase the probability of continuing the pregnancy until a favorable gestational age.Increase the interval between randomization and delivery. Decrease neonatal morbidity.
Study to determine if the drug 17-hydroxyprogesterone caproate can help reduce the risk of preterm delivery in women with certain risk factors for preterm birth. We hope to learn whether this same medication can be used to prolong pregnancy in a group of patients in whom this medication has not been previously studied. Specifically, we hope to learn whether progesterone supplementation will delay delivery in women with pre-term, premature rupture of membranes (PPROM).
Planned study is to determine if a weekly dose of Progesterone (17OHP) given to women with preterm rupture of the membranes will: 1.increase the probability of continuing the pregnancy until a favorable gestational age. 2.increase the interval between randomization and delivery.3.decrease neonatal morbidity.